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Table 2 Inhibition constants of C. cassia essential oil (CC-EO), trans -cinnamaldehyde and cis -2-methoxycinnamic acid for mushroom tyrosinase

From: Chemical composition and tyrosinase inhibitory activity of Cinnamomum cassia essential oil

Inhibitor CC-EO trans-cinnamaldehyde cis-2-methoxycinnamic acid
IC50 (mg/mL) 6.16 ± 0.04a* 4.04 ± 0.08* NS
Ki (mg/mL) 4.71 ± 0.09* 2.38 ± 0.09* NT
αKi (mg/mL) 15.50 ± 0.49* 9.61 ± 0.47* NT
Inhibition type Mixed Mixed NT
  1. aValues are presented as mean ± S.D. (n = 3). NS: tyrosinase inhibitory effect not shown; NT: not tested.
  2. *Means in the same parameter are significantly different (p < 0.05). Ki: dissociation constant for inhibitor binding with the free enzyme; αKi: dissociation constant for inhibitor binding with the enzyme-substrate complex.