Antihypertensive activity of (A) KTCGY and (B) KRIHF on systolic blood pressure of spontaneously hypertensive rats (SHRs). KTCGY or KRIHF at concentration of 10 mg/kg and 20 mg/kg was orally administered to the SHRs (6 rats/group), and the SBP were measured after 0, 2, 4, 6, 8, and 24 h by using an indirect tail-cuff blood pressure meter (BP98-A, Softron, Tokyo, Japan). Distilled water (0.5 ml) was administered to the SHRs in the blank group. The captopril (10 mg/kg) was used as the positive control. Data were expressed as mean ± S.D. For animal experiments, the differences between the blank and the experimental group at the same time was analyzed using Student’s t-test, and the P-value of less than 0.05 (*), 0.01 (**), and 0.001 (***) were recognized as different significantly.