Effects of dioscorin interventions (50 mg/kg) on (A) body weights, (B) feed intakes, (C) feed conversion (feed intakes/weight gains), and(D) weights of organ and fat tissues of high fat-diet induced obese rats. Arrow indicates the dioscorin intervention from day 36 to day 70. Data were expressed as mean ± SEM in the rat weight changes and others were expressed as mean ± SD. Multiple group comparisons under the same treated time were performed using one-way analysis of variance followed by the post hoc Tukey’s test, and values that have not been indicated with the same alphabet were significantly different (P < 0.05). HF, a high-fat diet; (HF diet + dio50), yam dioscorin (50 mg/kg, dio50) was intervened daily concurrent HF diet.