Effects of dioscorin interventions (50 mg/kg) on (A) systolic blood pressure and (B) diastolic blood pressures of high fat-diet induced obese rats. Blood pressure was measured at the end of each week after dioscorin intervention for 1-, 2-, 3-, and 4-weeks by using an indirect tail-cuff blood pressure meter (BP-98A, Softron Co. Ltd. Tokyo, Japan). Data were expressed as mean ± SD. Multiple group comparisons under the same treated time were performed using one-way analysis of variance followed by the post hoc Tukey’s test, and values that have not been indicated with the same alphabet were significantly different (P < 0.05). HF, a high-fat diet; (HF diet + dio50), yam dioscorin (50 mg/kg, dio50) was intervened daily concurrent HF diet.